Abstract
The interactions of cisplatin and its analogues, transplatin, carboplatin and oxaliplatin, with hen egg white lysozyme were analysed through ESI mass spectrometry, and the resulting metallodrug-protein adducts identified; the X-ray crystal structure of the cisplatin lysozyme derivative, solved at 1.9 A resolution, reveals selective platination of imidazole Nepsilon of His15.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Animals
-
Binding Sites
-
Carboplatin / chemistry
-
Carboplatin / metabolism
-
Chickens
-
Cisplatin / analogs & derivatives
-
Cisplatin / chemistry*
-
Cisplatin / metabolism
-
Crystallography, X-Ray
-
Egg White
-
Models, Molecular
-
Muramidase / chemistry*
-
Muramidase / metabolism
-
Organoplatinum Compounds / chemistry
-
Organoplatinum Compounds / metabolism
-
Oxaliplatin
-
Platinum Compounds / chemistry
-
Platinum Compounds / metabolism
-
Protein Binding
-
Protein Conformation
-
Spectrometry, Mass, Electrospray Ionization*
Substances
-
Organoplatinum Compounds
-
Platinum Compounds
-
Oxaliplatin
-
transplatin
-
Carboplatin
-
hen egg lysozyme
-
Muramidase
-
Cisplatin