Acridone and furoquinoline alkaloids from Teclea gerrardii (Rutaceae: Toddalioideae) of southern Africa

Alain F Kamdem Waffo; Philip H Coombes; Neil R Crouch; Dulcie A Mulholland; Sawsan M M El Amin; Peter J Smith

doi:10.1016/j.phytochem.2006.10.011

Acridone and furoquinoline alkaloids from Teclea gerrardii (Rutaceae: Toddalioideae) of southern Africa

Phytochemistry. 2007 Mar;68(5):663-7. doi: 10.1016/j.phytochem.2006.10.011. Epub 2006 Dec 15.

Authors

Alain F Kamdem Waffo¹, Philip H Coombes, Neil R Crouch, Dulcie A Mulholland, Sawsan M M El Amin, Peter J Smith

Affiliation

¹ School of Chemistry, University of KwaZulu-Natal, Howard College Campus, 4041, Durban, South Africa.

PMID: 17174364
DOI: 10.1016/j.phytochem.2006.10.011

Abstract

The combined hexane/CH(2)Cl(2) extract of the stem bark of Teclea gerrardii (Rutaceae: Toddalioideae) has yielded two acridone alkaloids, 3-hydroxy-1-methoxy-N-methylacridone (tegerrardin A) (1) and 3-hydroxy-N-methyl-1-(gamma,gamma-dimethylallyloxy)acridone (tegerrardin B) (2), three known acridones (3-5), two known furoquinolines (6,7), and the acridone precursor tecleanone (8). Arborinine (3) and evoxine (6) displayed moderate antiplasmodial activity against the CQS D10 strain of Plasmodium falciparum, with IC(50) values of 12.3 and 24.5 microM, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acridines / chemistry*
Acridines / isolation & purification
Acridines / pharmacology
Acridones
Alkaloids / chemistry*
Alkaloids / isolation & purification
Alkaloids / pharmacology
Animals
Antimalarials / chemistry*
Antimalarials / isolation & purification
Antimalarials / pharmacology
Cameroon
Plant Stems / chemistry
Plasmodium falciparum / drug effects*
Quinolines / chemistry*
Quinolines / isolation & purification
Quinolines / pharmacology
Rutaceae / chemistry*
Rutaceae / growth & development
South Africa

Substances

Acridines
Acridones
Alkaloids
Antimalarials
Quinolines
acridone