Abstract
Benign papular eruption on the left leg of a 72-year-old diabetic man developed into rapidly spreading necrotizing fasciitis despite antimicrobial therapy and surgical debridements. This led to eventual amputation to control the infection. The etiological agent was a Staphylococcus aureus isolate harboring the enterotoxin gene cluster seg, sei, sem, sen, and seo but lacked all common toxin genes, including Panton-Valentine leukocidin.
Publication types
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Case Reports
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Research Support, N.I.H., Extramural
MeSH terms
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Aged
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Anti-Bacterial Agents / pharmacology*
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Enterotoxins / genetics*
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Fasciitis, Necrotizing / microbiology*
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Fasciitis, Necrotizing / pathology
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Humans
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Leg / pathology
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Male
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Methicillin / pharmacology*
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Multigene Family*
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Staphylococcal Infections / microbiology
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Staphylococcal Infections / pathology
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / genetics
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Staphylococcus aureus / pathogenicity
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Superantigens / genetics
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Virulence
Substances
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Anti-Bacterial Agents
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Enterotoxins
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Superantigens
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enterotoxin G, staphylococcal
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enterotoxin I, staphylococcal
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Methicillin