Chemical modifications rescue off-target effects of RNAi

Ola Snøve Jr; John J Rossi

doi:10.1021/cb6002256

Chemical modifications rescue off-target effects of RNAi

ACS Chem Biol. 2006 Jun 20;1(5):274-6. doi: 10.1021/cb6002256.

Authors

Ola Snøve Jr¹, John J Rossi

Affiliation

¹ Division of Molecular Biology, Graduate School of Biological Sciences, Beckman Research Institute of the City of Hope, 1450 East Duarte Road, Duarte, California 91010, USA.

PMID: 17163754
DOI: 10.1021/cb6002256

Abstract

RNAi's specificity has been questioned for some time. Three recent papers show that off-target effects should be considered normal, but one paper also provides insight on how chemical modifications of siRNAs may overcome the problem.

Publication types

Review

MeSH terms

Animals
Gene Targeting / methods*
Humans
RNA Interference / physiology*
RNA, Small Interfering / chemistry*
RNA, Small Interfering / genetics*

Substances

RNA, Small Interfering