Synthesis and antiviral properties of aza-analogues of acyclovir

Mariola Koszytkowska-Stawińska; Katarzyna Kaleta; Wojciech Sas; Erik De Clercq

doi:10.1080/15257770601052281

Synthesis and antiviral properties of aza-analogues of acyclovir

Nucleosides Nucleotides Nucleic Acids. 2007;26(1):51-64. doi: 10.1080/15257770601052281.

Authors

Mariola Koszytkowska-Stawińska¹, Katarzyna Kaleta, Wojciech Sas, Erik De Clercq

Affiliation

¹ Faculty of Chemistry, Warsaw University of Technology, Warszawa, Poland. mkoszyt@ch.pw.edu.pl

PMID: 17162587
DOI: 10.1080/15257770601052281

Abstract

Aza-analogues of Acyclovir were obtained from N-(2-pivaloyloxyethyl)-N-(pivaloyloxymethyl)-p-toluenesulfonamide via a one-pot base silylation/nucleoside coupling procedure. The antiviral activities of all aza-nucleosides in vitro against a variety of viruses were evaluated. None of these compounds displayed any specific antiviral effects.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acyclovir / analogs & derivatives*
Animals
Antiviral Agents / chemical synthesis
Antiviral Agents / chemistry*
Antiviral Agents / pharmacology*
Chlorocebus aethiops
HeLa Cells
Humans
Nucleosides / chemical synthesis
Nucleosides / chemistry*
Nucleosides / pharmacology*
Sulfonamides / chemistry
Vero Cells
Viruses / drug effects

Substances

Antiviral Agents
N-(2-pivaloyloxyethyl)-N-(pivaloyloxymethyl)-4-toluenesulfonamide
Nucleosides
Sulfonamides
Acyclovir