Scavenging effect and antispasmodic activity of the essential oil of Cyclotrichium niveum

Fitoterapia. 2007 Feb;78(2):129-33. doi: 10.1016/j.fitote.2006.10.006. Epub 2006 Nov 14.

Abstract

The radical scavenging and the spasmolitic activity of Cyclotrichium niveum essential oil were evaluated in vitro. It showed an IC(50) of 1750 microg/ml on DPPH method and dose dependently (0.1, 0.5 and 1 mg/ml) inhibits the contraction induced by carbachol on rabbit bladder from 15 to 100%. Moreover, it was able to inhibit the rat ileum muscle by 30 to 100%.

MeSH terms

  • Animals
  • Biphenyl Compounds
  • Carbachol
  • Dose-Response Relationship, Drug
  • Female
  • Free Radical Scavengers / administration & dosage
  • Free Radical Scavengers / pharmacology*
  • Free Radical Scavengers / therapeutic use
  • Male
  • Muscle Contraction / drug effects*
  • Parasympatholytics / administration & dosage
  • Parasympatholytics / pharmacology*
  • Parasympatholytics / therapeutic use
  • Phytotherapy*
  • Picrates / chemistry
  • Plant Components, Aerial
  • Plant Oils / administration & dosage
  • Plant Oils / pharmacology*
  • Plant Oils / therapeutic use
  • Plants, Medicinal*
  • Rabbits
  • Rats
  • Rats, Wistar
  • Urinary Bladder / drug effects

Substances

  • Biphenyl Compounds
  • Free Radical Scavengers
  • Parasympatholytics
  • Picrates
  • Plant Oils
  • Carbachol
  • 1,1-diphenyl-2-picrylhydrazyl