Abstract
The radical scavenging and the spasmolitic activity of Cyclotrichium niveum essential oil were evaluated in vitro. It showed an IC(50) of 1750 microg/ml on DPPH method and dose dependently (0.1, 0.5 and 1 mg/ml) inhibits the contraction induced by carbachol on rabbit bladder from 15 to 100%. Moreover, it was able to inhibit the rat ileum muscle by 30 to 100%.
MeSH terms
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Animals
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Biphenyl Compounds
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Carbachol
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Dose-Response Relationship, Drug
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Female
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Free Radical Scavengers / administration & dosage
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Free Radical Scavengers / pharmacology*
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Free Radical Scavengers / therapeutic use
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Male
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Muscle Contraction / drug effects*
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Parasympatholytics / administration & dosage
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Parasympatholytics / pharmacology*
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Parasympatholytics / therapeutic use
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Phytotherapy*
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Picrates / chemistry
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Plant Components, Aerial
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Plant Oils / administration & dosage
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Plant Oils / pharmacology*
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Plant Oils / therapeutic use
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Plants, Medicinal*
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Rabbits
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Rats
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Rats, Wistar
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Urinary Bladder / drug effects
Substances
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Biphenyl Compounds
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Free Radical Scavengers
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Parasympatholytics
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Picrates
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Plant Oils
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Carbachol
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1,1-diphenyl-2-picrylhydrazyl