Outcomes of patients with haematological malignancies admitted to intensive care unit. A comparative review of allogeneic haematopoietic stem cell transplantation data

Br J Haematol. 2007 Feb;136(3):448-50. doi: 10.1111/j.1365-2141.2006.06440.x. Epub 2006 Dec 8.

Abstract

The outcomes of 55 consecutive haemato-oncology patients admitted to the intensive care unit (ICU) were retrospectively analysed. Twenty-eight patients were admitted following haemopoietic stem cell transplantation (HSCT). Thirty-nine patients were admitted with respiratory failure, and all patients required respiratory support. Seventeen patients survived to be discharged from ICU, with an actuarial 1-year survival of 18%. Overall survival between patients who received intensive chemotherapy and those who underwent allogeneic HSCT was not significantly different (19% vs. 10%, P = 0.19). None of the nine myeloablative HSCT recipients survived (median survival: 9 d). Six of the 15 reduced-intensity conditioned HSCT recipients survived beyond 1 year (median survival: 1050 d, range: 438-1437).

MeSH terms

  • Adult
  • Aged
  • Critical Care*
  • Female
  • Hematologic Neoplasms / complications
  • Hematologic Neoplasms / mortality
  • Hematologic Neoplasms / surgery*
  • Hematopoietic Stem Cell Transplantation* / mortality
  • Hospital Mortality
  • Humans
  • Intensive Care Units
  • Male
  • Middle Aged
  • Proportional Hazards Models
  • Remission Induction / methods
  • Respiratory Insufficiency / mortality
  • Respiratory Insufficiency / therapy
  • Retrospective Studies
  • Risk Factors
  • Survival Rate
  • Transplantation, Homologous
  • Treatment Outcome