Abstract
This paper describes DNA analog synthesis consisting of the benzene-phosphate backbone, of which the monomer units are built from benzene-core units connected via a biaryl-like axis to the nucleobases. It was found that the duplex comprised of the analogs had a non-helical structure and was thermally more stable than the corresponding natural DNA duplex.
MeSH terms
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Benzene / chemistry*
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Circular Dichroism
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Crystallography, X-Ray
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DNA / chemical synthesis*
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DNA / chemistry*
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DNA / radiation effects
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Nucleic Acid Conformation / radiation effects
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Nucleic Acid Heteroduplexes / radiation effects
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Organophosphorus Compounds / chemical synthesis
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Organophosphorus Compounds / chemistry
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Phosphates / chemistry*
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Transition Temperature
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Ultraviolet Rays
Substances
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Nucleic Acid Heteroduplexes
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Organophosphorus Compounds
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Phosphates
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phosphoramidite
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DNA
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Benzene