Enhancement of RNA cleavage activity of 10-23 DNAzyme by covalently introduced intercalator

Chem Commun (Camb). 2006 Dec 28:(48):5062-4. doi: 10.1039/b611078a. Epub 2006 Oct 13.

Abstract

By introducing an intercalator through D-threoninol to the 10-23 DNAzyme at the junction between its catalytic loop and the binding arm, the RNA cleavage activity was greatly improved.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anthraquinones / chemistry
  • Azo Compounds / chemistry
  • Azo Compounds / radiation effects
  • Base Sequence
  • Catalysis / radiation effects
  • DNA, Catalytic / chemistry*
  • DNA, Single-Stranded / chemistry*
  • Intercalating Agents / chemistry*
  • Isomerism
  • Kinetics
  • Light
  • Molecular Structure
  • Oligoribonucleotides / chemistry
  • Photochemistry
  • Pyrenes / chemistry
  • RNA / chemistry*
  • Threonine / analogs & derivatives
  • Threonine / chemistry
  • Ultraviolet Rays

Substances

  • Anthraquinones
  • Azo Compounds
  • DNA, Catalytic
  • DNA, Single-Stranded
  • Intercalating Agents
  • Oligoribonucleotides
  • Pyrenes
  • RNA-cleaving DNA 10-23
  • Threonine
  • RNA
  • azobenzene