Abstract
By introducing an intercalator through D-threoninol to the 10-23 DNAzyme at the junction between its catalytic loop and the binding arm, the RNA cleavage activity was greatly improved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anthraquinones / chemistry
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Azo Compounds / chemistry
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Azo Compounds / radiation effects
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Base Sequence
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Catalysis / radiation effects
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DNA, Catalytic / chemistry*
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DNA, Single-Stranded / chemistry*
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Intercalating Agents / chemistry*
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Isomerism
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Kinetics
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Light
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Molecular Structure
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Oligoribonucleotides / chemistry
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Photochemistry
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Pyrenes / chemistry
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RNA / chemistry*
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Threonine / analogs & derivatives
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Threonine / chemistry
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Ultraviolet Rays
Substances
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Anthraquinones
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Azo Compounds
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DNA, Catalytic
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DNA, Single-Stranded
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Intercalating Agents
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Oligoribonucleotides
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Pyrenes
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RNA-cleaving DNA 10-23
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Threonine
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RNA
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azobenzene