Using enzymatic reactions to enhance the photodynamic therapy effect of porphyrin dityrosine phosphates

Chem Commun (Camb). 2006 Dec 28:(48):5021-3. doi: 10.1039/b611557h. Epub 2006 Oct 12.

Abstract

This paper reports the synthesis and photodynamic therapy (PDT) effect of a porphyrin derivative containing tyrosine phosphate, which promises a new, useful approach to develop PDT agents.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Cell Survival / drug effects
  • Cell Survival / radiation effects
  • Dose-Response Relationship, Drug
  • Ethylamines / chemistry
  • HeLa Cells
  • Humans
  • Light
  • Molecular Structure
  • Phosphoric Monoester Hydrolases / chemistry*
  • Phosphoric Monoester Hydrolases / metabolism
  • Phosphotyrosine / chemistry*
  • Phosphotyrosine / metabolism
  • Photochemotherapy / methods
  • Photosensitizing Agents / chemistry*
  • Photosensitizing Agents / metabolism
  • Photosensitizing Agents / pharmacology
  • Porphyrins / chemistry*
  • Porphyrins / metabolism
  • Porphyrins / pharmacology
  • Protoporphyrins / chemistry
  • Spectrophotometry
  • Triazoles / chemistry
  • Urea / analogs & derivatives
  • Urea / chemistry

Substances

  • Ethylamines
  • Photosensitizing Agents
  • Porphyrins
  • Protoporphyrins
  • Triazoles
  • Phosphotyrosine
  • N,N-diisopropylethylamine
  • Urea
  • Phosphoric Monoester Hydrolases
  • 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate