High-intensity focused ultrasound (HIFU) continues to be a very attractive option for minimally invasive procedures. Using well-established principles, this ablative therapy can be used to treat a number of benign and malignant diseases with few side effects. During the last 15 years, there has been an enormous amount of work, both laboratory based and in the form of clinical trials, aimed at developing devices that can deliver treatments with safe and effective outcomes. In this article, we aim to outline the principles of HIFU, describe the current commercially available machines and their applications, and discuss the role of HIFU in the future.