Abstract
Rat lung mast cells were stimulated with drugs with distinct mechanisms of action, namely concanavalin A, compound 48/80 ionophore A23187, in the presence of the beta adrenergic agonist (-)isoproterenol. Cells show a high response when they are stimulated with FNa-calcium. Isoproterenol does not inhibit histamine release induced by any stimuli, but enhances the response to concanavalin A and compound 48/80. Results point to the lack of beta activity on rat lung mast cells.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Calcimycin / pharmacology
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Calcium / pharmacology
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Concanavalin A / pharmacology
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Drug Interactions
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Histamine Release / drug effects*
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Isoproterenol / pharmacology*
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Lung / cytology*
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Mast Cells / drug effects*
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Mast Cells / metabolism
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Rats
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Receptors, Adrenergic, beta / drug effects
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Receptors, Adrenergic, beta / physiology
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Sodium Fluoride / pharmacology
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p-Methoxy-N-methylphenethylamine / pharmacology
Substances
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Receptors, Adrenergic, beta
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Concanavalin A
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Calcimycin
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p-Methoxy-N-methylphenethylamine
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Sodium Fluoride
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Isoproterenol
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Calcium