[Effect of isoproterenol on the liberation of histamine from rat lung mast cells]

Rev Esp Fisiol. 1991 Mar;47(1):13-7.
[Article in Spanish]

Abstract

Rat lung mast cells were stimulated with drugs with distinct mechanisms of action, namely concanavalin A, compound 48/80 ionophore A23187, in the presence of the beta adrenergic agonist (-)isoproterenol. Cells show a high response when they are stimulated with FNa-calcium. Isoproterenol does not inhibit histamine release induced by any stimuli, but enhances the response to concanavalin A and compound 48/80. Results point to the lack of beta activity on rat lung mast cells.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Calcimycin / pharmacology
  • Calcium / pharmacology
  • Concanavalin A / pharmacology
  • Drug Interactions
  • Histamine Release / drug effects*
  • Isoproterenol / pharmacology*
  • Lung / cytology*
  • Mast Cells / drug effects*
  • Mast Cells / metabolism
  • Rats
  • Receptors, Adrenergic, beta / drug effects
  • Receptors, Adrenergic, beta / physiology
  • Sodium Fluoride / pharmacology
  • p-Methoxy-N-methylphenethylamine / pharmacology

Substances

  • Receptors, Adrenergic, beta
  • Concanavalin A
  • Calcimycin
  • p-Methoxy-N-methylphenethylamine
  • Sodium Fluoride
  • Isoproterenol
  • Calcium