Background: O2O3 therapy has become a largely diffused treatment for lumbar disk herniation; this procedure is considered generally risk-free.
Case description: We report a case of ventral and dorsal root injury occurring after transcutaneous intradiscal infiltration of O2O3 for L4-L5 disk herniation.
Conclusions: Until randomized controlled trials on efficacy and short-term safety have been carried out, we think that physicians should be informed about the risk of potential complications when recommending this procedure.