Abstract
Signals from the hypothalamus govern food intake and energy balance. A new study describes nesfatin-1, a hypothalamic and brainstem peptide whose expression decreases during fasting. Although central treatment with nesfatin-1 inhibited food intake and nesfatin-1 blockade increased food intake, the role and mechanism of nesfatin in energy balance remains unclear.
MeSH terms
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Animals
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Calcium-Binding Proteins / antagonists & inhibitors
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Calcium-Binding Proteins / metabolism*
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DNA-Binding Proteins / antagonists & inhibitors
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DNA-Binding Proteins / metabolism*
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Eating*
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Energy Metabolism* / drug effects
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Fasting / metabolism
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Gene Expression Regulation / drug effects
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Humans
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Hypothalamus / metabolism*
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Nerve Tissue Proteins / antagonists & inhibitors
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Nerve Tissue Proteins / metabolism*
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Nerve Tissue Proteins / pharmacology
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Nucleobindins
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Rats
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Signal Transduction* / drug effects
Substances
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Calcium-Binding Proteins
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DNA-Binding Proteins
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NUCB2 protein, human
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Nerve Tissue Proteins
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Nucb1 protein, rat
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Nucleobindins