A wapl a day keeps the sisters apart: wapl and cohesin dynamics

Dev Cell. 2006 Dec;11(6):754-5. doi: 10.1016/j.devcel.2006.11.010.

Abstract

Sister chromatids are held together by the cohesin complex from the time they are made until cell division. In recent articles published in Cell and Current Biology, the characterization of Wapl, a newly identified cohesin-interacting protein, suggests that a dynamic interaction between the cohesin complex and chromatin is important for normal regulation of sister chromatid cohesion.

Publication types

  • Editorial

MeSH terms

  • Animals
  • Cell Cycle Proteins / metabolism*
  • Chromatin / metabolism*
  • Chromosomal Proteins, Non-Histone / metabolism*
  • Cohesins
  • Humans
  • Mitosis / physiology*
  • Nuclear Proteins / metabolism*
  • Proteins / physiology*
  • Sister Chromatid Exchange / physiology*

Substances

  • Cell Cycle Proteins
  • Chromatin
  • Chromosomal Proteins, Non-Histone
  • Nuclear Proteins
  • Proteins
  • WAPL protein, mouse