Increased farnesylation of p21-Ras and neonatal macrosomia in women with gestational diabetes

J Pediatr. 2006 Dec;149(6):871-3. doi: 10.1016/j.jpeds.2006.08.071.

Abstract

Six of 22 mothers with gestational diabetes mellitus had infants with macrosomia, cord blood hyperinsulinemia, and increased amounts of a key mitogenic intermediate, farnesylated p21-Ras. The ability of fetal hyperinsulinemia to increase the availability of farnesylated p21-Ras may represent one mechanism of the growth-promoting action of insulin during fetal development.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Diabetes, Gestational / metabolism*
  • Female
  • Fetal Blood / chemistry*
  • Fetal Macrosomia / blood*
  • Fetal Macrosomia / metabolism
  • Humans
  • Infant, Newborn
  • Insulin / blood*
  • Leukocytes / chemistry*
  • Pregnancy
  • Protein Prenylation*
  • Proto-Oncogene Proteins p21(ras) / metabolism*

Substances

  • Insulin
  • Proto-Oncogene Proteins p21(ras)