The Simon effect refers to the performance advantage for responding to the nonspatial identity of the target when the target's irrelevant location corresponds with the relative location of the response. The present study is a parametric examination of the magnitude of the Simon effect across visual space. Response keys were arranged along vertical, horizontal, and two diagonal axes, and stimuli were arranged in two concentric circles (near and far from fixation) along the same axes. The results show that the Simon effect is of similar magnitude regardless of stimulus-response axis. In contrast to findings from stimulus-response compatibility paradigms, there was no evidence in this study for the presence of an orthogonal compatibility effect or left-right prevalence effect, suggesting that these effects only arise when response location is relevant. The results demonstrate the robust generalizability of the Simon effect under different spatial conditions and thus broaden the relevance of the Simon effect to a variety of applications.