Individuals with a moderate alcohol intake are at lower risk of heart disease than abstainers. In this study, we examined whether the frequency of alcohol intake plays a role in this association. Among men, we observed a low risk of coronary heart disease among frequent drinkers that was independent of the total weekly intake. Among women, we observed a low risk of coronary heart disease that was independent of the drinking frequency. These sex differences in the association of alcohol with coronary heart disease deserve more research.