Abstract
Staphylococci, common orthopedic pathogens, form antibiotic-resistant biofilms. Polymethylmethacrylate (PMMA) beads loaded with the quorum-sensing inhibitor RNAIII-inhibiting peptide (RIP) were implanted in rats and shown to prevent methicillin-resistant Staphylococcus aureus infection. RIP release was bimodal, typical of previously-tested antibiotics. These results suggest that RIP-PMMA warrants further evaluation for management of orthopedic infections caused by staphylococci.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Anti-Bacterial Agents / pharmacology
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Biofilms / drug effects*
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Biofilms / growth & development
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Disease Models, Animal
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Dose-Response Relationship, Drug
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Drug Carriers / chemistry*
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Male
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Microspheres
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Oligopeptides / pharmacology*
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Oligopeptides / therapeutic use
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Polymethacrylic Acids / chemistry*
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Rats
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Rats, Wistar
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Staphylococcal Infections / drug therapy
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Staphylococcal Infections / prevention & control
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Staphylococcus aureus / drug effects*
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Staphylococcus aureus / physiology*
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Vancomycin / pharmacology
Substances
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Anti-Bacterial Agents
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Drug Carriers
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Oligopeptides
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Polymethacrylic Acids
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RNAIII inhibiting peptide
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polymethacrylic acid
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Vancomycin