Abstract
SP produces two different muscular responses in the isolated vas deferens of the rat. 1) A myotropic, post-synaptic effect that results from stimulation of one subtype of SP receptor, located on the membrane of the smooth muscle (NK-3 receptor). 2) A neurogenic effect at the pre-synaptic level that results from stimulation of another subtype of SP receptor, located on the nerve terminals (NK-1 receptor).
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Dose-Response Relationship, Drug
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Electric Stimulation
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Male
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Muscle Contraction / drug effects
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Muscle, Smooth / drug effects
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Muscle, Smooth / innervation
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Muscle, Smooth / physiology
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Neurons / drug effects
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Rats
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Rats, Inbred Strains
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Receptors, Neurokinin-1
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Receptors, Neurotransmitter / metabolism*
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Substance P / pharmacology*
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Synapses / drug effects
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Synaptic Transmission / drug effects
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Vas Deferens / drug effects*
Substances
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Receptors, Neurokinin-1
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Receptors, Neurotransmitter
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Substance P