Pharmacological actions of substance P in the rat vas deferens

Neuropeptides. 1991 Apr;18(4):209-13. doi: 10.1016/0143-4179(91)90149-d.

Abstract

SP produces two different muscular responses in the isolated vas deferens of the rat. 1) A myotropic, post-synaptic effect that results from stimulation of one subtype of SP receptor, located on the membrane of the smooth muscle (NK-3 receptor). 2) A neurogenic effect at the pre-synaptic level that results from stimulation of another subtype of SP receptor, located on the nerve terminals (NK-1 receptor).

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Dose-Response Relationship, Drug
  • Electric Stimulation
  • Male
  • Muscle Contraction / drug effects
  • Muscle, Smooth / drug effects
  • Muscle, Smooth / innervation
  • Muscle, Smooth / physiology
  • Neurons / drug effects
  • Rats
  • Rats, Inbred Strains
  • Receptors, Neurokinin-1
  • Receptors, Neurotransmitter / metabolism*
  • Substance P / pharmacology*
  • Synapses / drug effects
  • Synaptic Transmission / drug effects
  • Vas Deferens / drug effects*

Substances

  • Receptors, Neurokinin-1
  • Receptors, Neurotransmitter
  • Substance P