The aim of the study was to investigate associations between combined defensin genotypes (CDGs) and somatic cell count (SCC) in Jersey cows. The study included a herd of 184 dairy Jersey cows from Wielkopolska region in Poland. Polymerase chain reaction-restriction fragment length polymorphism analysis with TaqI restrictase established the existence of 12 CDGs with a frequency of over 1%. The most frequent were A1A2B1B2C1C2 and A1A2B1B2C1- genotypes with a frequency of 56.9783% and 12.5% respectively. The study also confirmed the existence of a statistically significant association between SCC and the year of study, season, lactation stage and cow. The highest SCC (transformed into a logarithmic scale) was found in the milk of cows with A1-B1-C1C2 genotype, whereas the lowest one in cows with A2-B1B2C1C2 genotype. Another aim of the project was to study the association between CDG and milk production traits, such as daily milk yield and fat and protein content. CDG was found to be a significant factor affecting daily milk yield and non-significant for fat and protein content. The highest daily milk yield was observed in cows with CDGs A1A2B1B2C2- and -A2-B1B2C1-, whereas the lowest one was characteristic of -A2-B1-C1C2 and A1A2B1-C1- animals. Fat content was found to be related to CDG genotype in the opposite way; the highest values were recorded in animals with -A2-B1B2C1- genotype, the lowest - in animals with -A2-B1-C1C2 genotype. Similar results were observed in protein content in milk -A2-B1B2C1-, the highest content and -A2-B1-C1C2, the lowest content. The results confirm the hypothesis of using CDG as an SCC marker. However, further studies should be conducted to confirm these results before CDG can be used as a marker in a mass selection of dairy cows.