Enantiodiscrimination by NMR spectroscopy

Curr Pharm Des. 2006;12(31):4023-45. doi: 10.2174/138161206778743628.

Abstract

The analysis of enantiorecognition processes involves the detection of enantiomeric species as well as the study of chiral discrimination mechanisms. In both fields Nuclear Magnetic Resonance (NMR) spectroscopy plays a fundamental role, providing several tools, based on the use of suitable chiral auxiliaries, for observing distinct signals of enantiomers and for investigating the complexation phenomena involved in enantiodiscrimination processes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Data Interpretation, Statistical
  • Drug Contamination
  • Indicators and Reagents / chemistry
  • Lanthanoid Series Elements / chemistry
  • Magnetic Resonance Spectroscopy* / methods
  • Models, Chemical
  • Models, Molecular
  • Molecular Conformation
  • Organometallic Compounds / chemistry
  • Pharmaceutical Preparations / chemistry*
  • Selenium Compounds / chemistry
  • Solvents / chemistry
  • Stereoisomerism*
  • Structure-Activity Relationship

Substances

  • Indicators and Reagents
  • Lanthanoid Series Elements
  • Organometallic Compounds
  • Pharmaceutical Preparations
  • Selenium Compounds
  • Solvents