The phenomenon of transient apical ballooning is a rare underlying cause of severe left ventricular dysfunction and has been described as Tako-Tsubo-like cardiomyopathy. Acute myocarditis has been reported to masquerade as acute myocardial infarction or vice versa and is considered as differential diagnosis in this phenomenon. We present here a case of an adult female who was admitted to our cardiology department with chest pain, electrocardiographic and echocardiographic features, suggestive of an acute anterior myocardial infarction, preceded by physical and emotional stress. Coronary angiography demonstrated coronary arteries without relevant atherosclerotic lesions; left ventriculography showed a severe anteroapical dysfunction. Right ventricular endomyocardial biopsy showed normal cardiac tissue, but was positive for Parvovirus B19. Follow-up (2 months later) showed complete regression of regional wall motion abnormalities in transthoracic echocardiography.