Thiosialoside clusters using carbosilane dendrimer core scaffolds as a new class of influenza neuraminidase inhibitors

Jun-Ichi Sakamoto; Tetsuo Koyama; Daisei Miyamoto; Sangchai Yingsakmongkon; Kazuya I P J Hidari; Wipawee Jampangern; Takashi Suzuki; Yasuo Suzuki; Yasuaki Esumi; Ken Hatano; Daiyo Terunuma; Koji Matsuoka

doi:10.1016/j.bmcl.2006.10.085

Thiosialoside clusters using carbosilane dendrimer core scaffolds as a new class of influenza neuraminidase inhibitors

Bioorg Med Chem Lett. 2007 Feb 1;17(3):717-21. doi: 10.1016/j.bmcl.2006.10.085. Epub 2006 Nov 1.

Authors

Jun-Ichi Sakamoto¹, Tetsuo Koyama, Daisei Miyamoto, Sangchai Yingsakmongkon, Kazuya I P J Hidari, Wipawee Jampangern, Takashi Suzuki, Yasuo Suzuki, Yasuaki Esumi, Ken Hatano, Daiyo Terunuma, Koji Matsuoka

Affiliation

¹ Division of Materials Science, Graduate School of Science and Engineering, Saitama University, Sakura, Saitama 338-8570, Japan.

PMID: 17095224
DOI: 10.1016/j.bmcl.2006.10.085

Abstract

An efficient synthesis of a series of carbosilane dendrimers uniformly functionalized with alpha-thioglycoside of sialic acid was accomplished. The results of a preliminary study on biological responses against influenza virus sialidases using thiosialoside clusters showed that some of the glycodendrimers have inhibitory potencies against the sialidases.

MeSH terms

Dendrimers
Enzyme Inhibitors / chemical synthesis*
Enzyme Inhibitors / pharmacology*
Humans
Indicators and Reagents
Influenza A Virus, H1N1 Subtype / enzymology
Influenza A Virus, H3N2 Subtype / enzymology
Influenza A virus / enzymology*
Molecular Conformation
Neuraminidase / antagonists & inhibitors*
Spectrometry, Mass, Electrospray Ionization

Substances

Dendrimers
Enzyme Inhibitors
Indicators and Reagents
Neuraminidase