We present a patient with severe visual symptoms following multiple corneal refractive procedures including automated lamellar keratoplasty, arcuate keratotomy, laser in situ keratomileusis (LASIK), LASIK enhancement by cutting another flap, followed by a further LASIK enhancement by flap lifting. Topography was irregularly irregular, and the best spectacle-corrected visual acuity (BSCVA) was 20/25. Artemis very high-frequency digital ultrasound (US) analysis of the anatomical irregularities of the epithelium and stroma was used in conjunction with the topography to determine the cause of the visual symptoms. Very high-frequency digital US-assisted transepithelial phototherapeutic keratectomy together with a wavefront-guided treatment was used to reduce the stromal surface irregularities and the higher-order aberrations (HOAs), respectively. The treatment successfully regularized the stromal surface, dramatically reduced the HOAs, improved the contrast sensitivity to the high normal range, and improved the BSCVA to 20/20.