Design of endoperoxides with anti-Candida activity

Thomas D Avery; Peter I Macreadie; Ben W Greatrex; Tony V Robinson; Dennis K Taylor; Ian G Macreadie

doi:10.1016/j.bmc.2006.10.021

Design of endoperoxides with anti-Candida activity

Bioorg Med Chem. 2007 Jan 1;15(1):36-42. doi: 10.1016/j.bmc.2006.10.021. Epub 2006 Oct 31.

Authors

Thomas D Avery¹, Peter I Macreadie, Ben W Greatrex, Tony V Robinson, Dennis K Taylor, Ian G Macreadie

Affiliation

¹ Department of Chemistry, The University of Adelaide, 5005 SA, Australia.

PMID: 17079152
DOI: 10.1016/j.bmc.2006.10.021

Abstract

Broad antifungal structure-activity relationships governing epoxy-endoperoxides 2 and 3 and their parent endoperoxides 1 are reported. Their inhibitory activity against Candida albicans in conjunction with hemolytic activity and/or growth inhibition of cultured mammalian cells are reported. This information provided guidance for the further development of endoperoxide and epoxy-endoperoxides as topical antifungal agents.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antifungal Agents / chemical synthesis*
Antifungal Agents / chemistry
Antifungal Agents / pharmacology*
CHO Cells
Candida albicans / drug effects*
Cell Proliferation / drug effects
Cricetinae
Drug Design*
Erythrocytes / drug effects
Humans
Microbial Sensitivity Tests
Molecular Conformation
Peroxides / chemical synthesis*
Peroxides / chemistry
Peroxides / pharmacology*
Stereoisomerism
Structure-Activity Relationship

Substances

Antifungal Agents
Peroxides