Total synthesis of (+/-)-morphine

Kenji Uchida; Satoshi Yokoshima; Toshiyuki Kan; Tohru Fukuyama

doi:10.1021/ol062112m

Total synthesis of (+/-)-morphine

Org Lett. 2006 Nov 9;8(23):5311-3. doi: 10.1021/ol062112m.

Authors

Kenji Uchida¹, Satoshi Yokoshima, Toshiyuki Kan, Tohru Fukuyama

Affiliation

¹ Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

PMID: 17078705
DOI: 10.1021/ol062112m

Abstract

[Structure: see text] The morphinan skeleton was effectively synthesized by an intramolecular Mannich-type reaction. Further transformation led to total synthesis of morphine.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Molecular Structure
Morphine / chemical synthesis*

Substances

Morphine