Microalbuminuria is a well-known marker for cardiovascular and renal complications. The purpose of our study was to identify factors associated with microalbuminuria in individuals with resistant hypertension. Urine albumin excretion (UAE) was evaluated in 187 patients with resistant hypertension. The association between UAE and clinical, laboratory, and 24-h ABPM variables was investigated through comparison of means, correlation analysis, and logistic regression. A high prevalence of microalbuminuria was found (29.4%-95% CI: 22.9-36.5). In logistic regression, 24-h, HDL-cholesterol, serum creatinine, and diabetes mellitus were independently associated with UAE. Blood pressure control appears to be fundamental for reducing microalbuminuria. Moreover, early identification of individuals with microalbuminuria is of the utmost importance due to its association with cardiovascular and renal damage.