Genetic architecture of Hsp90-dependent drug resistance

Eukaryot Cell. 2006 Dec;5(12):2184-8. doi: 10.1128/EC.00274-06. Epub 2006 Oct 20.

Abstract

Hsp90 potentiates the evolution of azole resistance in the model yeast Saccharomyces cerevisiae and the opportunistic pathogen Candida albicans via calcineurin. Here, we explored effectors downstream of calcineurin regulating this Hsp90-dependent trait. Using S. cerevisiae erg3 mutants as a model, we determined that both Crz1 and Hph1 modulate azole resistance.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antifungal Agents / pharmacology
  • Calcineurin / metabolism
  • Drug Resistance, Fungal / genetics
  • Fluconazole / pharmacology
  • Genes, Fungal
  • HSP90 Heat-Shock Proteins / genetics*
  • HSP90 Heat-Shock Proteins / metabolism*
  • Mutation
  • Oxidoreductases / genetics
  • Oxidoreductases / metabolism
  • Saccharomyces cerevisiae / drug effects
  • Saccharomyces cerevisiae / genetics*
  • Saccharomyces cerevisiae / metabolism*
  • Saccharomyces cerevisiae Proteins / genetics*
  • Saccharomyces cerevisiae Proteins / metabolism*

Substances

  • Antifungal Agents
  • HSP82 protein, S cerevisiae
  • HSP90 Heat-Shock Proteins
  • Saccharomyces cerevisiae Proteins
  • Fluconazole
  • Oxidoreductases
  • sterol delta-5 desaturase
  • Calcineurin