Abstract
The design, synthesis, and biological evaluation of the 2-phenyl-isoindole-1,3-diones will be discussed. Detailed modeling studies with X-ray support were used to understand the ligand binding orientation and observed selectivity.
MeSH terms
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Crystallography, X-Ray
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Estrogen Receptor beta / agonists*
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Estrogen Receptor beta / chemistry
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Humans
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Indoles / chemical synthesis
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Indoles / chemistry*
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Ligands
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Phthalimides / chemical synthesis
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Phthalimides / chemistry*
Substances
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Estrogen Receptor beta
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Indoles
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Ligands
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Phthalimides