Pharmacokinetics of intravenous linezolid in cerebrospinal fluid and plasma in neurointensive care patients with staphylococcal ventriculitis associated with external ventricular drains

Antimicrob Agents Chemother. 2007 Jan;51(1):379-82. doi: 10.1128/AAC.00515-06. Epub 2006 Oct 16.

Abstract

The pharmacokinetic profile of linezolid in cerebrospinal fluid (CSF) in five neurointensive care patients with staphylococcal ventriculitis was studied. The mean area under concentration-time curve (+/- standard deviation) was 63 +/- 18.9 mg x h/liter, with a CSF-to-plasma ratio of 0.8 +/- 0.3. Times above MIC in CSF were 99.8% and 57.2% for pathogens with MICs of 2 mg/liter and 4 mg/liter, respectively.

Publication types

  • Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetamides / blood
  • Acetamides / cerebrospinal fluid
  • Acetamides / pharmacokinetics*
  • Adolescent
  • Adult
  • Aged
  • Area Under Curve
  • Cerebral Ventricles / drug effects*
  • Cerebral Ventricles / metabolism
  • Cerebral Ventricles / microbiology
  • Encephalitis / drug therapy*
  • Encephalitis / metabolism
  • Encephalitis / microbiology
  • Female
  • Humans
  • Injections, Intravenous
  • Linezolid
  • Male
  • Metabolic Clearance Rate
  • Microbial Sensitivity Tests
  • Middle Aged
  • Oxazolidinones / blood
  • Oxazolidinones / cerebrospinal fluid
  • Oxazolidinones / pharmacokinetics*
  • Staphylococcal Infections / drug therapy*
  • Staphylococcal Infections / microbiology
  • Staphylococcus / drug effects*

Substances

  • Acetamides
  • Oxazolidinones
  • Linezolid