Diagnosis of Paracoccidioidomycosis by detection of antigen and antibody in bronchoalveolar lavage fluids

Clin Vaccine Immunol. 2006 Dec;13(12):1363-6. doi: 10.1128/CVI.00239-06. Epub 2006 Oct 11.

Abstract

Paracoccidioidomycosis (PCM) is a systemic infection caused by the fungus Paracoccidioides brasiliensis and is believed to be the leading cause of fungal pulmonary infection. In this study, we used an inhibition enzyme-linked immunosorbent assay to diagnose pulmonary PCM based on the detection of 43-kDa and 70-kDa molecules in bronchoalveolar lavage fluids. The results were compared with results obtained by classical methods for antibody detection.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Fungal / analysis*
  • Antigens, Fungal / analysis*
  • Bronchoalveolar Lavage Fluid / immunology*
  • Bronchoalveolar Lavage Fluid / microbiology
  • Fungal Proteins / analysis
  • Glycoproteins / analysis
  • Humans
  • Lung Diseases, Fungal / immunology
  • Lung Diseases, Fungal / microbiology
  • Paracoccidioides / immunology*
  • Paracoccidioidomycosis / diagnosis*
  • Paracoccidioidomycosis / microbiology

Substances

  • 43 kDa protein, Paracoccidioides
  • Antibodies, Fungal
  • Antigens, Fungal
  • Fungal Proteins
  • Glycoproteins