Improving prediction of aerosol deposition in an idealized mouth using large-Eddy simulation

J Aerosol Med. 2006 Fall;19(3):290-300. doi: 10.1089/jam.2006.19.290.

Abstract

Monodisperse aerosol deposition in an idealized mouth geometry with a relatively small inlet diameter (D (in) = 3.0 mm) was studied numerically using a standard Large Eddy Simulation (LES). A steady inhalation flow rate of Q = 32.2 L/min was used. Thousands of particles (2.5, 3.7, and 5.0 microm in diameter and rho (f) = 912.0 kg/m(3) density) were released separately in the computational domain and aerosol deposition was determined. The total aerosol deposition results in this idealized mouth were in relatively good agreement when compared with measured data obtained in separate experiments, showing considerable improvement over the standard RANS/EIM (Reynolds Averaged Navier-Stokes/Eddy Interaction Model) approach.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aerosols*
  • Computer Simulation
  • Humans
  • Kinetics
  • Models, Statistical
  • Models, Theoretical
  • Mouth / anatomy & histology*
  • Mouth / drug effects
  • Movement
  • Particle Size
  • Pharmaceutical Preparations / administration & dosage*
  • Software

Substances

  • Aerosols
  • Pharmaceutical Preparations