Accessing tetrahydrofuran-based natural products by microbial Baeyer-Villiger biooxidation

Marko D Mihovilovic; Dario A Bianchi; Florian Rudroff

doi:10.1039/b606633j

Accessing tetrahydrofuran-based natural products by microbial Baeyer-Villiger biooxidation

Chem Commun (Camb). 2006 Aug 14:(30):3214-6. doi: 10.1039/b606633j. Epub 2006 Jun 19.

Authors

Marko D Mihovilovic¹, Dario A Bianchi, Florian Rudroff

Affiliation

¹ Vienna University of Technology, Institute of Applied Synthetic Chemistry, Getreidemarkt 9/163-OC, A-1060 Vienna, Austria. mmihovil@pop.tuwien.ac.at

PMID: 17028747
DOI: 10.1039/b606633j

Abstract

A heterobicyclic lactone obtained by stereoselective Baeyer-Villiger biooxidation with recombinant whole-cells expressing cyclopentanone monooxygenase from Comamonas sp. NCIMB 9872 was used for formal total syntheses of various natural products containing a tetrahydrofuran structural motif.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Biological Products / biosynthesis*
Biological Products / chemistry*
Comamonas / chemistry*
Comamonas / metabolism*
Furans / chemistry*
Furans / metabolism*
Molecular Structure
Oxidation-Reduction

Substances

Biological Products
Furans
tetrahydrofuran