Biosynthesis of quinolactacin A, a TNF production inhibitor

J Antibiot (Tokyo). 2006 Jul;59(7):418-27. doi: 10.1038/ja.2006.59.

Abstract

Quinolactacins, which inhibit tumor necrosis factor production, contain a quinolone skeleton conjugated with a y-lactam. The biosynthesis of quinolactacin was investigated by feeding experiments using 13C single-labeled precursors (sodium [1-13C]acetate, DL-[1-13C]-isoleucine, L-[methyl-13C]methionine, and sodium [1-13C]-anthranilate) and D-[U-13C]glucose.

MeSH terms

  • Molecular Structure
  • Penicillium / metabolism*
  • Quinolones / chemistry
  • Quinolones / metabolism
  • Quinolones / pharmacology
  • Tumor Necrosis Factor-alpha / antagonists & inhibitors
  • Tumor Necrosis Factor-alpha / biosynthesis*

Substances

  • Quinolones
  • Tumor Necrosis Factor-alpha
  • quinolactacin A