Studies on gynaecological hydrophilic lactic acid preparations, Part 7: use of chitosan as lactic acid carrier in intravaginal tablets (globuli vaginales)

Pharmazie. 2006 Sep;61(9):780-2.

Abstract

Intravaginal tablets based on hydrophilic methylcellulose and containing lactic acid complexed with chitosan undergo deformation under standard conditions. The high flow--limit of the gel originating from the tablets as well as its dynamic viscosity should ensure the durability of this dosage form on the vaginal mucosa. By selecting either ratios of lactic acid to chitosan of 1:1 or 2:1 it is possible to obtain tablets that disintegrate into a gel form at pH 3.8-4.4, i.e. the pH remains within the physiological range. Increasing the amount of lactic acid in the complex in relation to polymer to a 4:1 ratio results in gels with a lower pH while giving an acid reserve that can neutralize the excess of alkali present in severe vaginal infections.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adhesives
  • Administration, Intravaginal
  • Chemistry, Pharmaceutical
  • Chitosan
  • Drug Carriers
  • Gelatin
  • Gels
  • Hydrogen-Ion Concentration
  • Lactic Acid / administration & dosage*
  • Lactic Acid / chemistry
  • Methylcellulose
  • Pharmaceutic Aids
  • Tablets
  • Temperature
  • Viscosity

Substances

  • Adhesives
  • Drug Carriers
  • Gels
  • Pharmaceutic Aids
  • Tablets
  • Lactic Acid
  • Gelatin
  • Methylcellulose
  • Chitosan