A commentary on neuronal degeneration and cell death in Guam ALS and PD: an evolutionary process of understanding

Curr Alzheimer Res. 2006 Sep;3(4):397-401. doi: 10.2174/156720506778249425.

Abstract

The Twentieth Century witnessed tremendous advances in our understanding of neurodegenerative diseases. Not least among them were the contributions from hyperendemic foci of neurodegenerative disorders in isolated human groups worldwide, with the knowledge gained applicable to our understanding of related neurodegenerative diseases globally.

Publication types

  • Review

MeSH terms

  • Amyotrophic Lateral Sclerosis / genetics
  • Amyotrophic Lateral Sclerosis / metabolism
  • Amyotrophic Lateral Sclerosis / physiopathology*
  • Animals
  • Cell Death / drug effects
  • Cell Death / genetics
  • Environmental Exposure / adverse effects
  • Genetic Predisposition to Disease / genetics*
  • Guam / epidemiology
  • Humans
  • Mitochondrial Diseases / genetics
  • Mitochondrial Diseases / metabolism
  • Mitochondrial Diseases / physiopathology
  • Nerve Degeneration / genetics
  • Nerve Degeneration / metabolism
  • Nerve Degeneration / physiopathology*
  • Neurotoxins / metabolism
  • Neurotoxins / toxicity
  • Parkinson Disease / genetics
  • Parkinson Disease / metabolism
  • Parkinson Disease / physiopathology*

Substances

  • Neurotoxins