Regulation of ribosome biogenesis: where is TOR?

Dietmar E Martin; Ted Powers; Michael N Hall

doi:10.1016/j.cmet.2006.09.002

Regulation of ribosome biogenesis: where is TOR?

Cell Metab. 2006 Oct;4(4):259-60. doi: 10.1016/j.cmet.2006.09.002.

Authors

Dietmar E Martin¹, Ted Powers, Michael N Hall

Affiliation

¹ Biozentrum, University of Basel, Klingelbergstrasse 70, CH-4056 Basel, Switzerland.

PMID: 17011497
DOI: 10.1016/j.cmet.2006.09.002

Abstract

Li et al., (2006) have shown that TOR complex 1 in yeast binds directly to the rDNA promoter and thereby activates Pol I-dependent synthesis of 35S RNA. This is an important advance in the understanding of how ribosome biogenesis is regulated in response to environmental conditions.

Publication types

Review

MeSH terms

DNA, Ribosomal / genetics
DNA-Directed RNA Polymerases / metabolism
Gene Expression Regulation, Fungal
Phosphatidylinositol 3-Kinases / metabolism*
Phosphotransferases (Alcohol Group Acceptor) / metabolism*
RNA / biosynthesis*
Ribosomes / metabolism*
Saccharomyces cerevisiae / metabolism
Saccharomyces cerevisiae Proteins / metabolism*

Substances

DNA, Ribosomal
Saccharomyces cerevisiae Proteins
RNA
Phosphotransferases (Alcohol Group Acceptor)
TOR1 protein, S cerevisiae
DNA-Directed RNA Polymerases