Risk of iron overload in carriers of genetic mutations associated with hereditary haemochromatosis: UK Food Standards Agency workshop

Br J Nutr. 2006 Oct;96(4):770-3.

Abstract

The UK Food Standards Agency convened a group of expert scientists to review current research investigating diet and carriers of genetic mutations associated with hereditary haemochromatosis. The workshop concluded that individuals who are heterozygous for the C282Y mutation of the HFE gene do not appear to respond abnormally to dietary Fe and therefore do not need to change their diet to prevent accumulation of body Fe.

Publication types

  • Consensus Development Conference

MeSH terms

  • Atherosclerosis / etiology
  • Diet
  • Genetic Predisposition to Disease
  • Hemochromatosis / genetics
  • Hemochromatosis Protein
  • Heterozygote*
  • Histocompatibility Antigens Class I / genetics
  • Humans
  • Iron Overload / complications
  • Iron Overload / genetics*
  • Iron, Dietary / pharmacokinetics
  • Membrane Proteins / genetics
  • Mutation*

Substances

  • HFE protein, human
  • Hemochromatosis Protein
  • Histocompatibility Antigens Class I
  • Iron, Dietary
  • Membrane Proteins