Enhanced antiscrapie effect using combination drug treatment

Antimicrob Agents Chemother. 2006 Oct;50(10):3447-9. doi: 10.1128/AAC.00715-06.

Abstract

Combination treatment with pentosan polysulfate and Fe(III)meso-tetra(4-sulfonatophenyl)porphine in mice beginning 14 or 28 days after scrapie inoculation significantly increased survival times. This increase may be synergistic, implying that the compounds act cooperatively in vivo. Combination therapy may therefore be more effective for treatment of transmissible spongiform encephalopathies and other protein-misfolding diseases.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Cricetinae
  • Drug Synergism
  • Drug Therapy, Combination
  • Mice
  • Pentosan Sulfuric Polyester* / administration & dosage
  • Pentosan Sulfuric Polyester* / therapeutic use
  • Porphyrins* / administration & dosage
  • Porphyrins* / therapeutic use
  • Scrapie / drug therapy*
  • Scrapie / mortality
  • Survival Rate
  • Treatment Outcome

Substances

  • Porphyrins
  • tetraphenylporphine sulfonate
  • Pentosan Sulfuric Polyester