Comparing the regulatory behaviour of two cooperative, reversible enzyme mechanisms

B G Olivier; J M Rohwer; J L Snoep; J H S Hofmeyr

doi:10.1049/ip-syb:20060020

Comparing the regulatory behaviour of two cooperative, reversible enzyme mechanisms

Syst Biol (Stevenage). 2006 Sep;153(5):335-7. doi: 10.1049/ip-syb:20060020.

Authors

B G Olivier¹, J M Rohwer, J L Snoep, J H S Hofmeyr

Affiliation

¹ Triple-J Group for Molecular Cell Physiology, Department of Biochemistry, University of Stellenbosch, Stellenbosch 7600, South Africa. bgoli@sun.ac.za

PMID: 16986311
DOI: 10.1049/ip-syb:20060020

Abstract

It is shown that both the reversible Hill equation and a generalised, reversible Monod-Wyman-Changeux equation can give analogous regulatory behaviour when embedded in a model metabolic pathway.

Publication types

Comparative Study

MeSH terms

Catalysis
Coenzymes / chemistry*
Computer Simulation
Enzyme Activation
Feedback
Models, Chemical*
Models, Molecular*
Multienzyme Complexes / chemistry*
Substrate Specificity

Substances

Coenzymes
Multienzyme Complexes