Experimental model of hemorrhagic stroke: rabbit immunization with HL-60 promyelocytic cell differentiation factor

M V Gapon; S M Dranitsyna; N I Minkevich; M A Gruden'; I I Babichenko; I A Kostanyan

doi:10.1007/s10517-006-0147-7

Experimental model of hemorrhagic stroke: rabbit immunization with HL-60 promyelocytic cell differentiation factor

Bull Exp Biol Med. 2006 Feb;141(2):272-4. doi: 10.1007/s10517-006-0147-7.

Authors

M V Gapon¹, S M Dranitsyna, N I Minkevich, M A Gruden', I I Babichenko, I A Kostanyan

Affiliation

¹ Laboratory of Hormonal Regulation Proteins, M M Shemyakin and Yu A Ovchinnikov Institute of Organic Biochemistry, Russian Academy of Sciences.

PMID: 16984116
DOI: 10.1007/s10517-006-0147-7

Abstract

Rabbits immunized with synthetic HLDF differentiation factor developed hemorrhagic stroke with thrombosis of small cerebral vessels and destruction of vascular endotheliocytes. The severity of stroke correlated with serum level of antibodies to differentiation factor. The role of different sites of HLDF molecule in the induction of clinical signs of hemorrhagic stroke was studied.

MeSH terms

Animals
Brain / pathology
Cerebral Hemorrhage / etiology
Cerebral Hemorrhage / immunology
Cerebral Hemorrhage / pathology
Disease Models, Animal
HL-60 Cells
Humans
Immunization
Male
Models, Biological
Neoplasm Proteins / immunology*
Rabbits
Stroke / etiology*
Stroke / immunology
Stroke / pathology

Substances

Neoplasm Proteins
cell differentiation factor 8.2-kDa