Mouse and human cell activation by N-dodecanoyl-DL-homoserine lactone, a Chromobacterium violaceum autoinducer

Infect Immun. 2006 Dec;74(12):7029-31. doi: 10.1128/IAI.00038-06. Epub 2006 Sep 18.

Abstract

Chromobacterium violaceum produces autoinducers, including homoserine lactones (HSLs), for genetic regulation. Among the seven HSLs derived from C. violaceum we evaluated, only C(12)-HSL stimulated the production of inflammatory cytokines in mammalian monocytic cell lines through the activation of the NF-kappaB signaling pathway besides their quorum-sensing role, like 3-oxo-C(12)-HSL from Pseudomonas aeruginosa.

MeSH terms

  • 4-Butyrolactone / analogs & derivatives*
  • 4-Butyrolactone / metabolism
  • 4-Butyrolactone / pharmacology
  • Animals
  • Cells, Cultured
  • Chromobacterium / metabolism*
  • Cytokines / metabolism*
  • Homoserine / analogs & derivatives*
  • Homoserine / metabolism
  • Homoserine / pharmacology
  • Humans
  • Macrophage Activation
  • Macrophages / drug effects*
  • Macrophages / immunology
  • Mice
  • Monocytes / drug effects*
  • Monocytes / immunology
  • NF-kappa B / agonists

Substances

  • Cytokines
  • N-dodecanoyl-DL-homoserine lactone
  • NF-kappa B
  • Homoserine
  • 4-Butyrolactone