New dihydrodibenzoxepins from Bulbophyllum kwangtungense

Planta Med. 2006 Oct;72(13):1244-7. doi: 10.1055/s-2006-947200. Epub 2006 Sep 18.

Abstract

Three new dihydrodibenzoxepins 7,8-dihydro-5-hydroxy-12,13-methylenedioxy-11-methoxyldibenz[ B,F]oxepin (1), 7,8-dihydro-4-hydroxy-12,13-methylenedioxy-11-methoxyldibenz[ B,F]oxepin (2), and 7,8-dihydro-3-hydroxy-12,13-methylenedioxy-11-methoxyldibenz[ B,F]oxepin (3), were isolated from Bulbophyllum kwangtungense Schlecht, along with three known compounds, cumulatin (4), densiflorol A (5) and plicatol B (6). Their structures were established by a combination of 1D and 2D NMR spectroscopic techniques. All new compounds (1-3) and the known compound densiflorol A (5) exhibited anti-tumor activities against HeLa and K562 human tumor cell lines.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents, Phytogenic / chemistry
  • Antineoplastic Agents, Phytogenic / isolation & purification
  • Antineoplastic Agents, Phytogenic / pharmacology*
  • Cell Line, Tumor
  • Dibenzoxepins / chemistry
  • Dibenzoxepins / isolation & purification
  • Dibenzoxepins / pharmacology*
  • Humans
  • Molecular Conformation
  • Nuclear Magnetic Resonance, Biomolecular
  • Orchidaceae / chemistry*

Substances

  • Antineoplastic Agents, Phytogenic
  • Dibenzoxepins