Quantum dot encapsulation in viral capsids

Suraj K Dixit; Nancy L Goicochea; Marie-Christine Daniel; Ayaluru Murali; Lyudmila Bronstein; Mrinmoy De; Barry Stein; Vincent M Rotello; C Cheng Kao; Bogdan Dragnea

doi:10.1021/nl061165u

Quantum dot encapsulation in viral capsids

Nano Lett. 2006 Sep;6(9):1993-9. doi: 10.1021/nl061165u.

Authors

Suraj K Dixit¹, Nancy L Goicochea, Marie-Christine Daniel, Ayaluru Murali, Lyudmila Bronstein, Mrinmoy De, Barry Stein, Vincent M Rotello, C Cheng Kao, Bogdan Dragnea

Affiliation

¹ Department of Chemistry, Indiana University, Bloomington, Indiana 47405, USA.

PMID: 16968014
DOI: 10.1021/nl061165u

Abstract

Incorporation of CdSe/ZnS semiconductor quantum dots (QDs) into viral particles provides a new paradigm for the design of intracellular microscopic probes and vectors. Several strategies for the incorporation of QDs into viral capsids were explored; those functionalized with poly(ethylene glycol) (PEG) can be self-assembled into viral particles with minimal release of photoreaction products and enhanced stability against prolonged irradiation.

Publication types

Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Capsid / chemistry*
Coated Materials, Biocompatible / chemistry*
Molecular Probe Techniques*
Nanotechnology / methods*
Quantum Dots*
Virus Assembly

Substances

Coated Materials, Biocompatible

Grants and funding

GM59249/GM/NIGMS NIH HHS/United States