Bayes factor for testing the genetic background of quantitative threshold traits

J Anim Breed Genet. 2006 Oct;123(5):301-6. doi: 10.1111/j.1439-0388.2006.00606.x.

Abstract

The recent development of the Bayes factor methodology to test between nested competing models has allowed to evaluate the genetic component of continuous traits through a methodology based on the reparameterization of a variance component model in terms of intra-class correlation. In this study, we present a modification of that procedure to compare between threshold models that only differ in a bounded variable. An extra data-augmentation step is required to sample liability, an underlying continuous variable related with phenotypic records through an adequate number of thresholds. In this context, we describe a procedure to sample from a truncated multivariate normal distribution with non-null covariances between records, taking as starting point the Cholesky factorization and the inclusion of linear restrictions. The method was tested by computer simulations with satisfactory results.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bayes Theorem*
  • Computer Simulation
  • Genetic Testing
  • Models, Statistical*
  • Quantitative Trait, Heritable*