Mass spectral and NMR spectral data of two new designer drugs with an alpha-aminophenone structure: 4'-methyl-alpha-pyrrolidinohexanophenone and 4'-methyl-alpha-pyrrolidinobutyrophenone

Folker Westphal; Thomas Junge; Peter Rösner; Giselher Fritschi; B Klein; Ulrich Girreser

doi:10.1016/j.forsciint.2006.07.024

Mass spectral and NMR spectral data of two new designer drugs with an alpha-aminophenone structure: 4'-methyl-alpha-pyrrolidinohexanophenone and 4'-methyl-alpha-pyrrolidinobutyrophenone

Forensic Sci Int. 2007 Jun 14;169(1):32-42. doi: 10.1016/j.forsciint.2006.07.024. Epub 2006 Sep 7.

Authors

Folker Westphal¹, Thomas Junge, Peter Rösner, Giselher Fritschi, B Klein, Ulrich Girreser

Affiliation

¹ Landeskriminalamt Schleswig-Holstein, Sachgebiet Toxikologie/Betäubungsmittel, Mühlenweg 166, 24116 Kiel, Germany. dr.-folker.westphal@polizei.landsh.de

PMID: 16962275
DOI: 10.1016/j.forsciint.2006.07.024

Abstract

This study presents and discusses the nuclear magnetic resonance (NMR) spectroscopic and mass spectroscopic data of the new designer drug 4'-methyl-alpha-pyrrolidinobutyrophenone (MPBP) and its homolog 4'-methyl-alpha-pyrrolidinohexanophenone (MPHP) which were seized in 2004 and 2000 in Germany for the first time. The structure elucidation of the aliphatic part of MPBP was carried out by product ion spectroscopy of the immonium ion formed after electron ionization as well as with 1H and 13C NMR. Product ion spectroscopy of immonium ions again proved to be a powerful tool to determine the structure of designer drugs and to distinguish between isobaric structures of the alkyl-amino moiety.