Correlation of biological activity with active site binding modes of geminal disulfone HIV-1 integrase inhibitors

ChemMedChem. 2006 Sep;1(9):959-64. doi: 10.1002/cmdc.200600040.
No abstract available

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Binding Sites
  • Catalysis
  • HIV Integrase / chemistry
  • HIV Integrase / metabolism*
  • HIV Integrase Inhibitors / chemical synthesis*
  • HIV Integrase Inhibitors / pharmacology*
  • HIV-1 / drug effects*
  • HIV-1 / enzymology*
  • Humans
  • Hydrogen Bonding
  • Models, Molecular
  • Sulfones / chemical synthesis
  • Sulfones / chemistry*
  • Sulfones / pharmacology*

Substances

  • HIV Integrase Inhibitors
  • Sulfones
  • HIV Integrase