Increase of the M phenotype among erythromycin-resistant Streptococcus pneumoniae isolates from Spain related to the serotype 14 variant of the Spain9V-3 clone

Antimicrob Agents Chemother. 2006 Sep;50(9):3162-5. doi: 10.1128/AAC.00269-06.

Abstract

Between 1998 and 2003 the rate of erythromycin resistance among pneumococci in Spain was 34.4%. Although the MLS(B) phenotype was prevalent (94.7%), the rate of the M phenotype increased from 3.3% to 8.9% (P < 0.01). Clonal dissemination of mef(E)-carrying strains of serotype 14 variant of the Spain(9V)-3 clone was the major contributor to this increase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anti-Bacterial Agents / pharmacology*
  • Bacterial Proteins / genetics
  • Drug Resistance, Bacterial
  • Erythromycin / pharmacology*
  • Humans
  • Membrane Proteins / genetics
  • Pneumococcal Infections / epidemiology
  • Pneumococcal Infections / microbiology
  • Spain / epidemiology
  • Streptococcus pneumoniae / classification*
  • Streptococcus pneumoniae / drug effects*
  • Streptococcus pneumoniae / genetics
  • Streptococcus pneumoniae / isolation & purification

Substances

  • Anti-Bacterial Agents
  • Bacterial Proteins
  • MefA protein, Streptococcus
  • Membrane Proteins
  • Erythromycin