Treatment of familial male-limited precocious puberty with bicalutamide and anastrozole

J Pediatr. 2006 Sep;149(3):416-20. doi: 10.1016/j.jpeds.2006.04.027.

Abstract

This report describes the use of bicalutamide and anastrozole in two subjects with familial male-limited precocious puberty. Clinical improvements include decreased facial acne and pubic hair. Most importantly, a marked decrease in growth velocity and skeletal advancement has been achieved.

Publication types

  • Case Reports

MeSH terms

  • Anastrozole
  • Androgen Antagonists / therapeutic use*
  • Anilides / therapeutic use*
  • Aromatase Inhibitors / therapeutic use*
  • Child
  • Child, Preschool
  • Humans
  • Male
  • Mutation / genetics
  • Nitriles / therapeutic use*
  • Puberty, Precocious / drug therapy*
  • Puberty, Precocious / genetics
  • Receptors, LH / genetics
  • Tosyl Compounds
  • Triazoles / therapeutic use*

Substances

  • Androgen Antagonists
  • Anilides
  • Aromatase Inhibitors
  • Nitriles
  • Receptors, LH
  • Tosyl Compounds
  • Triazoles
  • Anastrozole
  • bicalutamide