Abstract
This report describes the use of bicalutamide and anastrozole in two subjects with familial male-limited precocious puberty. Clinical improvements include decreased facial acne and pubic hair. Most importantly, a marked decrease in growth velocity and skeletal advancement has been achieved.
MeSH terms
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Anastrozole
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Androgen Antagonists / therapeutic use*
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Anilides / therapeutic use*
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Aromatase Inhibitors / therapeutic use*
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Child
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Child, Preschool
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Humans
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Male
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Mutation / genetics
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Nitriles / therapeutic use*
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Puberty, Precocious / drug therapy*
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Puberty, Precocious / genetics
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Receptors, LH / genetics
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Tosyl Compounds
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Triazoles / therapeutic use*
Substances
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Androgen Antagonists
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Anilides
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Aromatase Inhibitors
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Nitriles
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Receptors, LH
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Tosyl Compounds
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Triazoles
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Anastrozole
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bicalutamide